Continental SNPs go public: New ancestry informative markers for follow-up association studies
نویسندگان
چکیده
منابع مشابه
CoAIMs: A Cost-Effective Panel of Ancestry Informative Markers for Determining Continental Origins
BACKGROUND Genetic ancestry is known to impact outcomes of genotype-phenotype studies that are designed to identify risk for common diseases in human populations. Failure to control for population stratification due to genetic ancestry can significantly confound results of disease association studies. Moreover, ancestry is a critical factor in assessing lifetime risk of disease, and can play an...
متن کاملApplication of Ancestry Informative Markers to Association Studies in European Americans
Recently, whole genome association (WGA) studies have accelerated progress in the search for genetic variations underlying the inheritance of complex genetic diseases. Although population differences in allele frequencies are usually small, these studies have demonstrated the importance of accounting for population differences in order to reduce false positive associations. Even within a contin...
متن کاملTracing Cattle Breeds with Principal Components Analysis Ancestry Informative SNPs
The recent release of the Bovine HapMap dataset represents the most detailed survey of bovine genetic diversity to date, providing an important resource for the design and development of livestock production. We studied this dataset, comprising more than 30,000 Single Nucleotide Polymorphisms (SNPs) for 19 breeds (13 taurine, three zebu, and three hybrid breeds), seeking to identify small panel...
متن کاملTwo Birds, One Stone: Selecting Functionally Informative Tag SNPs for Disease Association Studies
Selecting an informative subset of SNPs, generally referred to as tag SNPs, to genotype and analyze is considered to be an essential step toward effective disease association studies. However, while the selected informative tag SNPs may characterize the allele information of a target genomic region, they are not necessarily the ones directly associated with disease or with functional impairment...
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ژورنال
عنوان ژورنال: Human Mutation
سال: 2009
ISSN: 1059-7794,1098-1004
DOI: 10.1002/humu.20965